Digoxin. Digoxin (Lanoxin) is a heart medication. Taking Xanax with digoxin could cause digoxin to make up in your overall body. Your doctor may observe your digoxin level and lessen your digoxin dosage if necessary.To find out more about the probable negative effects of Xanax, begin to see the “Xanax side effects” portion over.Xanax and Ativan